Fig. 7. LB inhibits DNA repair in vivo.

a Alkaline comet assay was performed in 4T1 cells as described above. b Mice were treated i.v. with Doxo in combination with the indicated LB concentrations (i.p.) and mouse condition and weight observed for 48 h (two mice per condition). c Mice were injected with 1 × 10⁶ 4T1 cells (s.c.) and tumors grown up to 9 days. Mice were then treated with the indicated substances for 24 h, tumor cells isolated, and alkaline comet assay performed. Exemplary images are shown (scale bar 5 µm), values normalized on untreated mice (n = 11), *p < 0.05, one-way ANOVA, Sidak’s multiple comparisons test