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. 2019 Apr 3;10:1519. doi: 10.1038/s41467-019-09469-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Proteogenomic study of childhood B-cell precursor acute lymphoblastic leukemia (ALL). a Genomic landscape of 27 childhood ALL included in the proteogenomic analysis. All cases were disomic for chromosomes 2, 19, and 20. b Numbers of proteins overlapping across the 3 TMT-sets. c Spearman’s rank order correlation between mRNA and protein abundance. The correlation was positive for 77.6% mRNA-protein pairs in the whole cohort of cases with a mean Spearman’s correlation coefficient of 0.24. Approximately 23% mRNA-protein pairs showed significant correlation (multiple-test adjusted P ≤ 0.05). d When investigating different biological processes, mRNA and protein levels displayed the highest correlation for specialized pathways, such as hematopoietic cell lineage and amino acid metabolism, and lowest for house-keeping functions, e.g., ribosomal and spliceosomal processes