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. 2019 Apr 3;10:1519. doi: 10.1038/s41467-019-09469-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Low CTCF/cohesin expression and transcriptional dysregulation in high hyperdiploid leukemia. a Boxplots of the expression of CTCF and members of the cohesin complex in proteomics (top) and RiboZero RNA-sequencing datasets (bottom). Low expression of CTCF/cohesin complex members was seen in the high hyperdiploid subgroup at both the RNA and protein levels. The center of the boxplot is the median and lower/upper hinges correspond to the first/third quartiles; whiskers are 1.5 times the interquartile range and data beyond this range are plotted as individual points. b Spearman’s correlation coefficient between gene pairs as a function of distance across the oligo(dT) RNA-sequencing dataset for ETV6/RUNX1-positive cases (left; n = 39) and high hyperdiploid ALL (right; n = 44). The analysis showed that the expression of gene pairs in the same topologically associating domain (TAD; red) displayed higher correlation than those in different domains (blue) or randomly selected regions (gray) in ETV6/RUNX1-positive cases, whereas no difference was seen in high hyperdiploid ALL, suggesting that transcriptional dysregulation in hyperdiploid cases is related to TAD borders