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. 2019 Apr 3;10:1519. doi: 10.1038/s41467-019-09469-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Weaker topologically associating domain (TAD) boundaries in high hyperdiploid samples. a Median standardized directionality index profiles around TAD boundaries identified in high hyperdiploid cases (red), ETV6/RUNX1-positive cases (blue) and the GM12878 cell line (black). Two high hyperdiploid cases (HeH_9 and HeH_10) showed markedly decreased boundary strength, indicating permissive TAD boundaries. b Median insulation score around the TAD boundaries identified in high hyperdiploid cases (red), ETV6/RUNX1-positive cases (blue) and the GM12878 cell line (black). Three high hyperdiploid cases (HeH_9, HeH_10, and HeH_48) showed decreased insulation signal amplitude suggesting weaker insulation between TADs compared to the remaining samples