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. 2019 Apr 3;10(4):303. doi: 10.1038/s41419-019-1545-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a AP was induced in BALB/c mice with cerulein (100 μg/kg × 10) after 3 weeks of transfection with AAV-9-miR-155 or AAV-9-miR-155 sponge. The mice were sacrificed under anesthesia 24 h after the last injection of cerulein. b Serum amylase (U/L) and serum lipase (U/L) activity (n = 8 per group, *P < 0.05, **P < 0.01). c–e H&E staining of pancreas tissue from each group showing different levels of tissue damage, including pancreatic edema, extravascular infiltration and acinar cell necrosis (×200). Immunohistochemical staining and quantification of MPO revealed inflammation in the pancreas (×200) (n = 8 per group, *P < 0.05). f IF staining for caspase-1 in the pancreas (×200)