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. 2019 Mar 28;13:119. doi: 10.3389/fncel.2019.00119

Figure 2.

Figure 2

The rate of spontaneous AP activity increased with age, changing from bursting to Poisson-like firing. (A) Interspike interval (ISI) distribution over time for BCs (left) and SCs (right) from P12 (upper panels), P14 (middle panels), and P30 (lower panels). In each panel, representative 10 s voltage traces show the succession of AP discharges. Panels to the right show Gaussian fits to the probability of ISIs for the respective BCs and SCs. Note the loss of longer ISIs with maturity and only a single distribution in a P14 BC, as opposed to two distributions in a P14 SC. (B) Spontaneous firing rates increased during the development of both cell types (effect of cell type p < 0.001, effect of age p < 0.001, interaction cell type × age p = 0.6; two-way ANOVA). (C) Coefficient of variation (CVspont) values decreased with development in both cell types being smaller in BCs than in SCs (effect of cell type p < 0.001, effect of age p < 0.001, interaction cell type × age p = 0.05; two-way ANOVA). (D) The number of bursts generated during 100 s periods at different ages. Note that only a small portion of BCs still generated bursts at P12 and P13 (effect of cell type p = 0.002, effect of age p < 0.001, interaction cell type × age p = 0.1; two-way ANOVA). (E) The duration of bursts decreased similarly between P12 and P13 in both cells types (effect of cell type p = 0.07, effect of age p = 0.04, interaction cell type × age p = 0.44; two-way ANOVA). Note the absence of bursts in P14 BCs (*p < 0.05, **p < 0.01).