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. 2019 Mar 28;13:119. doi: 10.3389/fncel.2019.00119

Figure 4.

Figure 4

Development of temporal response properties to tone burst stimulation. (A) Peristimulus time histograms (PSTHs) of representative BCs and SCs at P12 (top) and P30 (bottom); bin width 0.5 ms. Insets show an enlargement of the first 20 ms of respective responses. Note the characteristic primary-like pattern of BC (bottom left) and chopping pattern of SC (bottom right) at P30. At P12 (upper panels), response latencies are longer in both cell types and SCs lacks chopping discharge pattern. (B) BCs and SCs show comparable CVPSTH values at P12–14 which diverge from P18 on (effect of cell type p < 0.001, effect of age p < 0.001, interaction cell type × age p < 0.001; two-way ANOVA). Dots indicate values of individual units; box-plots show medians, 25th and 75th percentiles, and the interdecile ranges. (C) First spike latency (FSL) decreases with age in both cells types, with overall lower values in BCs (effect of cell type p < 0.001, effect of age p < 0.001, interaction cell type × age p = 0.009; two-way ANOVA). (D) Recovery of spontaneous discharge activity after stimulus offset in BCs. Each trace shows averaged data for 6–10 cells. Spontaneous firing for each cell was calculated as the mean of 150 post-sound stimulation periods. Inset shows time constant values calculated from the fit (single exponential for P12 and P13, bi-exponential for P18 and P30) to the averaged data for each age group (mean ± standard deviation (SD), p < 0.001; one-way ANOVA) [*p < 0.05, **p < 0.01; ***p < 0.001].