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. 2019 Apr 3;9:5562. doi: 10.1038/s41598-019-41724-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intratumorally administrated DTA-1 Ab transferred into tumor draining lymph node. (a) Peritumoral injection of DTA-1 Ab. Fifty μg of DTA-1 Ab was injected directly into tumor (IT) or injected into subcutaneous space around the tumor (PT) (n = 8). Tumor volumes were measured at the indicated days. P value for DTA-1 IP vs PT, as analysed by t-test. (b) Immunohistochemical staining of tumor draining lymph nodes (TDLNs) for Rat IgG (DTA-1). DTA-1 Ab was intratumorally injected, and TDLNs were harvested 4 and 24 hours after Ab injection. (c) Detection of DTA-1 Ab in TDLNs. The transfer of DTA-1 Ab into TDLNs was compared between intraperitoneal injection (IP) and intratumoral injection (IT). Immunohistochemical staining of TDLNs was performed sequentially 1, 3 and 5 days after DTA-1 Ab injection. (d) Immunohistological score of DTA-1 Ab in TDLNs. Immunohistochemical scoring criteria are defined in Materials and Methods. Crossbar means the average. P value for DTA-1 IP vs IT on day 5, as analysed by t-test.