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. 2019 Mar 28;10:238. doi: 10.3389/fphys.2019.00238

Figure 2.

Figure 2

Western blotting (A) and quantitative analysis (B) to measure VEGFR-1/Flt-1 and VEGFR-2/Flk-1 expression in hearts from trained and control mice. (B) VEGFR-1/Flt-1 protein levels resulted significantly higher in T15 than in groups C, T30, and T45. Conversely, T45 animals showed a lower VEGFR-1/Flt-1 expression than C and T30 mice ($p < 0.05 T15 vs. T30 and T45; £p < 0.05 T45 vs. C and T30). VEGFR-2/Flk-1 expression gradually increased in trained mice (T15, T30, and T45) than control ones. Moreover, VEGFR-2/Flk-1 expression was higher in groups T30 and T45 than T15 ones and in T45 mice than T30 ones (*p < 0.05, T15, T30 and T45 vs. C; #p < 0.05, T30 and T45 vs. T15; §p < 0.05,T45 vs. T30).