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. 2019 Mar 28;10:625. doi: 10.3389/fmicb.2019.00625

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Copyright © 2019 Fu, Zhang, Zhang, Xu, Wang, Jin and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EV71 infection downregulated miR-17-92 cluster. (A) The heatmap showed the expression level of members of miR-17-92 cluster in mock- and EV71-infected HT-29 cells by small RNA deep sequencing. (B) Expression of mature miRNAs of the miR-17-92 cluster was analyzed in EV71-infected HT-29 cells at indicated time points by real-time quantitative PCR, using U6 rRNA as an internal control. Values were mean of triplicate experiments and presented in relative to the level of the mock infection. Mock infection was assigned with a value of 1. The data were presented as mean ± SEM (n = 3, ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001). (C) RT-PCR analysis of the pri-miR-17-92 cluster expression in EV71-infected cells at indicated time points normalized against GAPDH transcript levels.