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. 2019 Mar 28;10:180. doi: 10.3389/fphar.2019.00180

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Copyright © 2019 Cui, Wang, Wang, Jia and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Total Ion Chromatogram of GD. (A) The Total Ion Chromatogram of GD (ESI+). (ESI+) represents the positive ion detection mode, in which the mass analyzer scans only positive charged ions and filters out negative charged ions to obtain positive charged ions information during the detection process. (B) The Total Ion Chromatogram of GD (ESI–). (ESI–) denotes the negative ion detection mode, in which the mass analyzer scans only negative charged ions and filters out positive charged ions, thus obtaining the information of negative charged ions.