. 2019 Mar 29;10:1–8. doi: 10.1016/j.ijpddr.2019.03.003

Table 1.

Trypanocidal activity of AS-48 and BZN on the three developmental forms of T. cruzi strains. Toxicity on Vero cells.

Comp.	Activity IC₅₀ (μM)^a			Activity IC₅₀ (μM)^a			Activity IC₅₀ (μM)^a			Toxicity IC₅₀/72 h (μM) Vero cell
	Arequipa strain			SN3 strain			Tulahuen strain
	E/72 h	A/72 h	T/24 h	E/72 h	A/72 h	T/24 h	E/72 h	A/72 h	T/24 h
BZN	16.86 ± 1.81	8.25 ± 0.72	12.35 ± 1.14	36.51 ± 2.44	16.62 ± 1.46	36.09 ± 3.12	19.72 ± 1.75	9.96 ± 0.84	15.09 ± 1.30	80.35 ± 7.08
AS-48	0.76 ± 0.11	0.99 ± 0.13	0.17 ± 0.04	1.16 ± 0.18	6.81 ± 0.89	0.11 ± 0.02	0.82 ± 0.11	1.98 ± 0.22	0.19 ± 0.03	93.06 ± 5.67

IC₅₀ = concentration (μM) required to inhibit 50% population, calculated using GraphPad Prism 6. Results are averages of three separate determinations ± standard deviation. E, epimastigote forms. A, amastigote forms. T, trypomastigote forms.