. 2019 Mar 29;10:1–8. doi: 10.1016/j.ijpddr.2019.03.003

Table 2.

Selectivity Index for AS-48 and BZN on extra- and intracellular forms of T. cruzi strains.

Comp.	Selectivity index			Selectivity index			Selectivity index
	Arequipa strain^a			SN3 strain^a			Tulahuen strain^a
	E	A	T	E	A	T	E	A	T
BZN	4.77	9.73	6.51	2.20	4.83	2.23	4.07	8.07	5.32
AS-48	122.45	94.00	547.41	80.22	13.67	846.00	113.49	47.00	489.79
AS-48/BZN^b	26	10	84	36	3	379	28	6	92

Selectivity index (SI) = IC₅₀ Vero cells/IC₅₀ extracellular and intracellular form of parasite. ^bNumber of times that AS-48 exceeds the reference drug SI (on extracellular and intracellular forms of T. cruzi). E, epimastigote forms. A, amastigote forms. T, trypomastigote forms.