Table 1.
Potential miRNA biomarkers of perinatal hypoxia-ischemia.
| miRNA biomarkers of perinatal HI | Studied cohorts/subjects | Sampling source | Techniques employed for miRNA detection | References |
|---|---|---|---|---|
| ↓ miR-374a | 70 newborn infants | Umbilical cord blood | Microarray, qRT-PCR | Looney et al., 2015 |
| 18 controls, 33 with perinatal asphyxia in the absence of HIE, 19 infants with HIE | ||||
| ↑ miR-374a | 13 newborn piglets | Plasma sample | qRT-PCR | Garberg et al., 2016 |
| ↑ miR-210 | 5 controls, 8 with transient global HI | |||
| ↑ miR-210 | P10 rat pups | Ipsilateral hemisphere | qRT-PCR | Ma et al., 2016 |
| 4 controls, 4 with right carotid ligation induced HI | ||||
| ↑ miR-21 | 78 newborn infants | Serum sample | qRT-PCR | Chen and Yang, 2015 |
| 29 controls, 49 with asphyxia | ||||
| ↑ miR-210 | 24 infants | Maternal whole blood sample | qRT-PCR | Whitehead et al., 2013 |
| ↑ miR-424 | 12 controls, 12 severely growth restricted preterms | |||
| ↑ miR-21 | ||||
| ↑ miR-199a | ||||
| ↑ miR-20b | ||||
HIE: hypoxic-ischemic encephalopathy, HI: hypoxia-ischemia, qRT-PCR: quantitative real-time polymerase chain reaction.