Table 2.
Characteristics of CLDN18‐ARHGAP‐positive and ‐negative tumors in patients with gastric cancer
| Negative (n = 124) | Positive (n = 22) | P value | |
|---|---|---|---|
| Sex, n (%) | |||
| Male | 63 (50.8) | 8 (36.4) | .252 |
| Female | 61 (49.2) | 14 (63.6) | |
| Location of primary tumor, n (%) | |||
| Upper third | 38 (30.6) | 3 (13.6) | .168 |
| Middle third | 55 (44.4) | 10 (45.5) | |
| Lower third | 31 (25.0) | 9 (40.9) | |
| Lauren classification, n (%) | |||
| Intestinal | 10 (8.1) | 0 (0.0) | .360 |
| Diffuse | 114 (91.9) | 22 (100.0) | |
| Gross appearance, n (%) | |||
| Early | 64 (51.6) | 8 (36.4) | .169 |
| Type 2 | 10 (8.1) | 0 (0.0) | |
| Type 3 | 30 (24.2) | 10 (45.5) | |
| Type 4 | 17 (13.7) | 3 (13.6) | |
| Others | 3 (2.4) | 1 (4.5) | |
| Tumor size (cm) | |||
| 10< | 20 (16.1) | 8 (36.4) | .038 |
| ≤10 | 104 (83.9) | 14 (63.6) | |
| Depth of invasion, n (%) | |||
| m/sm | 51 (41.1) | 5 (22.7) | .121 |
| mp | 17 (13.7) | 1 (4.5) | |
| ss | 16 (12.9) | 5 (22.7) | |
| se/si | 40 (32.3) | 11 (50.0) | |
| LN metastasis, n (%) | |||
| Absent | 72 (58.1) | 4 (18.2) | <.001 |
| Present | 52 (41.9) | 18 (81.8) | |
| Stage (JGCA 14th edition) | |||
| Stage I/II | 85 (68.5) | 6 (27.3) | <.001 |
| Stage III/IV | 39 (26.7) | 16 (72.7) | |
Patients with fusion had more association with large tumor, metastatic lymph nodes (LNs), and advanced stage.
JGCA, Japanese Gastric Cancer Association m, mucosa; mp, muscularis propria; se, tumor penetration of serosa; si, tumor invasion of adjacent structures; sm, submucosa; ss, subserosa.