Figure 2.

Frizzled 2 (FZD2) promotes hepatocellular carcinoma cell proliferation in vitro and in vivo. A, Knockdown of FZD2 in SNU387 and SNU449 cells and overexpression of FZD2 were confirmed by quantitative RT‐PCR and western blot analysis. B, Cell growth was determined by CCK‐8 assay. C, Tumor size (left panels), weight (middle panels), and volume (right panels) of xenografts harvested at 30 days after s.c. injection of FZD2‐knockdown SNU449 cells and FZD2‐overexpressing HepG2 cells in nude mice. *P < .05, **P < .01. NC, negative control