Figure 5.

Frizzled 2 (FZD2) confers hepatocellular carcinoma (HCC) cells with vasculogenic mimicry (VM) ability. A, Representative images of VM with H&E staining in HCC tissues from cohort 2. The VM channel was periodic acid‐Schiff (PAS)⁺, but it did not express CD34. Endothelium‐dependent vessel was CD34⁺. B, FZD2 expression is positively correlated with the existence of a VM structure in HCC tissues from cohort 2. C, Representative images of tube formation by FZD2‐knockdown SNU387 and SNU449 cells and FZD2‐overexpressing HepG2 cells after 3D culture; numbers of tube‐like structures are shown. *P < .05, **P < .01. NC, negative control