Figure 5.

Programmed cell death ligand 1 (PD‐L1) disruption in tumors promotes anti‐tumor immunity by increasing tumor‐infiltrating lymphocytes. A‐F, CD4⁺ T cells, CD8⁺ T cells, natural killer (NK) cells (CD49), Treg cells (Foxp3), macrophages (F4/80) and PD‐1⁺ immune cells in the tumor microenvironment of mice transplanted with PD‐L1 KO ID8 and control ID8 on day 70. Representative results from 6 independent experiments are shown. Red arrowheads indicate positive cells. Original magnification, ×400. Bar = 50 μm. The number of CD4⁺ T cells, CD8⁺ T cells, NK cells (CD49), Treg cells (Foxp3), macrophages (F4/80) and PD‐1⁺ immune cells from peritoneally disseminated tumors of ID8. All values represent the mean ± SE (n = 6 in each group). Statistical significance determined by Student's t test; ***P < .001