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. 2019 Mar 18;17(5):4032–4038. doi: 10.3892/etm.2019.7408

Figure 2.

Figure 2.

AIFM1 is a direct target gene of miR-425-5p. (A) TargetScan software was used to predict a binding site for miR-425-5p in the 3′UTR of AIFM1. (B) Luciferase activity of a dual-luciferase reporter vector containing wild-type 3′UTR-AIFM1 or a mutant 3′UTR-AIFM1. Data are presented as the mean ± standard deviation of three independent experiments. **P<0.01 vs. mimic control. AIFM1, apoptosis-inducing factor mitochondria-associated 1; UTR, untranslated region; miR, microRNA; WT, wild-type; MUT, mutant-type; WT-AIFM1, HeLa cells co-transfected with WT 3′UTR-AIFM1 and either mimic control or miR-425-5p; MUT-AIFM1, HeLa cells co-transfected with MUT 3′UTR-AIFM1 and either mimic control or miR-425-5p.