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. 2019 Mar 20;17(5):4259–4266. doi: 10.3892/etm.2019.7422

Figure 5.

Figure 5.

miR-181a-5p inhibition significantly reverses the effects of CCAT1 knockdown in EC cells. (A) Following miR-181a-5p inhibition, the relative expression level of miR-181a-5p was detected in KLE cells by reverse transcription-quantification polymerase chain reaction. (B) The CCK-8 assay was used to analyze the effect of CCAT1 knockdown and miR-181a-5p inhibition on KLE cell proliferation. (C) The Transwell migration assay was used to analyze the effect of CCAT1 knockdown and miR-181a-5p inhibition on KLE cell migration. *P<0.05 as indicated. CCAT1, colon cancer-associated transcript 1; EC, endometrial cancer; miR, microRNA; KLE, human endometrial stromal cell line; NC, negative control; NC inhibitor, endometrial cancer cell line KLE transfected with negative control inhibitor; miR-181a-5p inhibitor, endometrial cancer cell line KLE transfected with miR-181a-5p inhibitor; si-control, endometrial cancer cell line KLE transfected with siRNA negative control; si-CCAT1, endometrial cancer cell line KLE transfected with siRNA targeting CCAT1; siRNA, small interfering RNA; si-CCAT1 + inhibitor, endometrial cancer cell line KLE transfected with siRNA targeting CCAT1 and miR-181a-5p inhibitor.