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. 2019 Mar 5;17(5):4463–4473. doi: 10.3892/ol.2019.10110

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Differential expression of exosomal miR-375. (A) Non-coding RNA classification. The average miRNA percentage in the sample was 6.51%. (B) Scatter plot of differences in miRNA expression. The upregulated miRNAs are indicated with red dots, downregulated miRNAs are indicated with green dots, and the miRNAs that were not significantly different are indicated with grey dots. (C) Heatmap of differences in miRNA expression levels. Red, upregulated; black, intermediate value; green, downregulated. Cut-off: |log2(fold-change)|≥1. A1, A2, A3: LNCaP cells; B1, B2, B3: RWPE-1 cells. (D) Volcano plot of differences in miRNA expression levels. Red, upregulated; grey, intermediate value; green, downregulated. (E) Relative expression levels of miR-375 in exosomes. *P<0.05 and **P<0.01 vs. RWPE-1 exo. exo, exosome; miR/miRNA, microRNA.