Inhibition of ZEB1 suppresses 786-O and A498 cell proliferation and invasion. (A) The relative protein expression level of ZEB1 was determined by western blot analysis in 786-O and A498 cells at 48 h following transfection with ZEB1 siRNA or NC siRNA. Cell (B) proliferation and (C) invasion were examined using CCK-8 and in vitro Transwell invasion assays, respectively, in 786-O and A498 cells at 48 h following transfection with ZEB1 siRNA or NC siRNA. *P<0.05 vs. NC siRNA. ZEB1, zinc finger E-box binding homeobox 1; siRNA, small interfering RNA; NC, negative control.