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. 2019 Mar 8;17(5):3775–3780. doi: 10.3892/etm.2019.7365

Figure 2.

Figure 2.

Matrine inhibits the phosphorylation levels of Akt and Foxo3a in RC-4B/C cells. (A) RC-4B/C cells were treated with matrine at the concentration of 0, 0.1, 0.5 and 2.5 mg/ml for 24 h. The levels of p-Akt, total Akt, p-Foxo3a and total Foxo3a were determined by western blotting analysis. β-actin was used as internal reference gene in pituitary cancer cells. (B) The gray values of p-Akt, total Akt, p-Foxo3a and total Foxo3a were shown in histogram in matrine-treated RC-4B/C cells. **P<0.01, compared with the pituitary cancer cells without matrine. p-Akt, phosphorylated Akt; p-Foxo3a, phosphorylated Foxo3a.