Table I.
Gene ontology analysis of differentially expressed genes associated with nasopharyngeal carcinoma.
| Gene name | Term/gene function | Gene count | P-value |
|---|---|---|---|
| FN1, ITGAV, ADAM23, DSG2, SSX2IP, COL5A1, LAMB1, CNTNAP2 | GO:0007155/cell adhesion | 8 | <0.01 |
| CCND2, HELLS, AURKA, SMC4, NDC80, HAUS6 | GO:0051301/cell division | 6 | <0.01 |
| HAUS6, NDC80, ANLN, AURKA, HELLS | GO:0007067/mitosis | 5 | <0.01 |
| SMC4, RFC4, NUP107, NDC80, TYMS, AURKA | GO:0000278/mitotic cell cycle | 6 | <0.01 |
| FN1, COL5A1, COL22A1, ITGAV, COL4A1 | GO:0030198/extracellular matrix organization | 5 | <0.01 |
| LAMB1, FZD7, FN1 | GO:0034446/substrate adhesion-dependent cell spreading | 3 | <0.01 |
| CXCL10, NTRK2 | GO:0010996/response to auditory stimulus | 2 | <0.01 |
| RFC4, NDC80, AURKA, TYMS | GO:0048015/phosphatidylinositol-mediated signaling | 4 | <0.01 |
| COL4A1, LHX2, LAMB1, ITGAV, COL5A1 | GO:0007411/axon guidance | 5 | <0.01 |
| TYMS, MTHFD2 | GO:0046653/tetrahydrofolate metabolic process | 2 | <0.01 |
| TYMS, HOXA3, PRRX1 | GO:0051216/cartilage development | 3 | <0.01 |
| FN1, COL4A1, ITGAV, HOXA3 | GO:0001525/angiogenesis | 4 | <0.01 |
| NTRK2, ARNT2, ITGAV, HOXA3, CXCL10 | GO:0008284/positive regulation of cell proliferation | 5 | <0.01 |
| RIF1, NDC80, CCND2, AURKA | GO:0007049/cell cycle | 4 | <0.01 |
| NUP107, SMC4, NDC80 | GO:0000236/mitotic prometaphase | 3 | <0.01 |
| SMC4, NDC80 | GO:0000070/mitotic sister chromatid segregation | 2 | <0.01 |
| AURKA, NDC80 | GO:0007051/spindle organization | 2 | <0.01 |
| FZD7, GRB10 | GO:0042327/positive regulation of phosphorylation | 2 | <0.01 |
| FN1, LAMB1, COL5A1 | GO:0016477/cell migration | 3 | <0.01 |
| RFC4, DTL, TYMS | GO:0006260/DNA replication | 3 | <0.01 |
| CNTNAP2, NTRK2 | GO:0021987/cerebral cortex development | 2 | <0.01 |
| GJA1, OLFM1 | GO:0051259/protein oligomerization | 2 | <0.01 |
| DMD, CNTNAP2 | GO:0034613/cellular protein localization | 2 | <0.01 |
| NTRK2 | GO:0048935/peripheral nervous system neuron development | 1 | 0.04 |
| NTRK2 | GO:0050773/regulation of dendrite development | 1 | 0.04 |
| DMD | GO:0060314/regulation of ryanodine-sensitive calcium-release channel activity | 1 | 0.04 |
| RIF1, DTL | GO:0006974/response to DNA damage stimulus | 2 | 0.04 |
| NTRK2, AURKA | GO:0046777/protein autophosphorylation | 2 | 0.04 |
| SRSF10 | GO:0006376/mRNA splice site selection | 1 | 0.04 |
| FZD7 | GO:0010812/negative regulation of cell-substrate adhesion | 1 | 0.04 |
| TFRC | GO:0045780/positive regulation of bone resorption | 1 | 0.04 |
| GJA1 | GO:0060174/limb bud formation | 1 | 0.04 |
| LHX2 | GO:2000678/negative regulation of transcription regulatory region DNA binding | 1 | 0.04 |
| NUP107, NDC80 | GO:0000090/mitotic anaphase | 2 | 0.05 |
| HELLS | GO:0001655/urogenital system development | 1 | 0.05 |
| GNLY | GO:0031640/killing of cells of other organism | 1 | 0.05 |
| CXCL10 | GO:0033280/response to vitamin D | 1 | 0.05 |
| SRSF10 | GO:0048025/negative regulation of mRNA splicing, via spliceosome | 1 | 0.05 |
| DSG2 | GO:0086005/regulation of ventricular cardiac muscle cell action potential | 1 | 0.05 |
| DNAAF1, DNAAF3, DRC1, CCDC39 | GO:0070286/axonemal dynein complex assembly | 4 | <0.01 |
| DNAH12, DNAH5, DNAH9, DYNLRB2, DYNC2H1, DNAH10, KIF9 | GO:0007018/microtubule-based movement | 7 | <0.01 |
| RSPH4A, RSPH9, DNAAF1 | GO:0003341/cilium movement | 3 | <0.01 |
| AK7, RSPH4A, RSPH9 | GO:0035083/cilium axoneme assembly | 3 | <0.01 |
| AKR1C2, AKR1C3, DHRS9 | GO:0042448/progesterone metabolic process | 3 | <0.01 |
| MUC4, MUC16, MUC5AC, MUC1, MUC20 | GO:0016266/O-glycan processing | 5 | <0.01 |
| ELF3, DHRS9, EZR, UPK1B | GO:0030855/epithelial cell differentiation | 4 | <0.01 |
| AKR1C3, AKR1C2 | GO:0034694/response to prostaglandin stimulus | 2 | <0.01 |
| ANKRD45, CFAP53, SORBS2, SCGB2A1, TMEM125, DNAH5, MUC4, MSMB, RSPH14, LRRC34, VNN3 | GO:0008150/biological_process | 11 | <0.01 |
| DNAAF1, DNAAF3 | GO:0044458/motile cilium assembly | 2 | <0.01 |
| DYNC2H1, ROPN1L, DNAH5 | GO:0001539/ciliary or flagellar motility | 3 | <0.01 |
| RDH10, DHRS9 | GO:0002138/retinoic acid biosynthetic process | 2 | <0.01 |
| DNAAF1, CCDC114 | GO:0036158/outer dynein arm assembly | 2 | <0.01 |
| DRC1, CCDC39 | GO:0060286/flagellar cell motility | 2 | <0.01 |
| AKR1C2, AKR1C3 | GO:0071395/cellular response to jasmonic acid stimulus | 2 | <0.01 |
| GPRC5A, CDS1, CALM1, RIIAD1, CCL15, EPAS1, CHL1, RRAD, ROPN1L, CEACAM6, GNAL, SCGB1A1, CAPN5 | GO:0007165/signal transduction | 13 | <0.01 |
| SERPINB4, WFDC2, SLPI, SERPINB3 | GO:0010951/negative regulation of endopeptidase activity | 4 | <0.01 |
| CHST6, CKB, ADH1C, CALM1, AKR1C3, SGMS2, ASS1, NQO1, SLC44A4, CHST9, CDS1, AK1, DHCR24, CH25H, GSTA1 | GO:0044281/small molecule metabolic process | 15 | <0.01 |
| SPAG6, DNAH9, PIFO | GO:0030030/cell projection organization | 3 | <0.01 |
| DYNC2H1, DNAI2, B9D1, CC2D2A | GO:0042384/cilium assembly | 4 | <0.01 |
| CCDC39, DNAAF1 | GO:0035469/determination of pancreatic left/right asymmetry | 2 | <0.01 |
| DRC1, CCDC39 | GO:0060285/ciliary cell motility | 2 | <0.01 |
| CCDC39, DNAAF1 | GO:0071907/determination of digestive tract left/right asymmetry | 2 | <0.01 |
| CCDC39, DNAAF1 | GO:0071910/determination of liver left/right asymmetry | 2 | <0.01 |
DEGs, differentially expressed genes.