Table II.
Kyoto Encyclopedia Analysis of Genes and Genomes pathway analysis of DEGs associated with nasopharyngeal carcinoma.
| Pathway ID | Name | Gene count | P-value | Genes |
|---|---|---|---|---|
| 04512 | ECM-receptor interaction | 5 | <0.01 | ITGAV, COL4A1, FN1, HMMR, LAMB1 |
| 05165 | Human papillomavirus infection | 6 | <0.01 | FZD7, ITGAV, LAMB1, CCND2, COL4A1, FN1 |
| 05412 | Arrhythmogenic right ventricular cardiomyopathy | 4 | <0.01 | DMD, GJA1, ITGAV, DSG2 |
| 04510 | Focal adhesion | 5 | <0.01 | LAMB1, FN1, ITGAV, CCND2, COL4A1 |
| 05222 | Small cell lung cancer | 4 | <0.01 | ITGAV, FN1, COL4A1, LAMB1 |
| 05200 | Pathways in cancer | 6 | <0.01 | ARNT2, FN1, LAMB1, FZD7, COL4A1, ITGAV |
| 04151 | PI3K-Akt signaling pathway | 5 | <0.01 | FN1, COL4A1, CCND2, ITGAV, LAMB1 |
| 04974 | Protein digestion and absorption | 3 | <0.01 | COL22A1, COL4A1, COL5A1 |
| 05146 | Amoebiasis | 3 | <0.01 | LAMB1, COL4A1, FN1 |
| 00670 | One carbon pool by folate | 2 | <0.01 | MTHFD2, TYMS |
| 00250 | Alanine, aspartate and glutamate metabolism | 2 | <0.01 | GAD1, ASNS |
| 05205 | Proteoglycans in cancer | 3 | <0.01 | FZD7, FN1, ITGAV |
| 05410 | Hypertrophic cardiomyopathy | 2 | 0.01 | ITGAV, DMD |
| 05414 | Dilated cardiomyopathy | 2 | 0.01 | DMD, ITGAV |
| 04933 | AGE-RAGE signaling pathway in diabetic complications | 2 | 0.02 | FN1, COL4A1 |
| 04620 | Toll-like receptor signaling pathway | 2 | 0.02 | CXCL11, CXCL10 |
| 03040 | Spliceosome | 2 | 0.03 | U2SURP, SRSF10 |
| 04550 | Signaling pathways regulating pluripotency of stem cells | 2 | 0.03 | FZD7, RIF1 |
| 04310 | Wnt signaling pathway | 2 | 0.04 | FZD7, CCND2 |
| 04514 | Cell adhesion molecules (CAMs) | 2 | 0.04 | ITGAV, CNTNAP2 |
| 04150 | mTOR signaling pathway | 2 | 0.04 | GRB10, FZD7 |
| 04145 | Phagosome | 2 | 0.04 | ITGAV, TFRC |
| 04390 | Hippo signaling pathway | 2 | 0.04 | FZD7, CCND2 |
| 00430 | Taurine and hypotaurine metabolism | 1 | 0.04 | GAD1 |
| 01100 | Metabolic pathways | 16 | <0.01 | DHRS9, CDS1, CKB, AK7, ADH1C, RDH10, SGMS2, DHCR24, AK1, ALDH3A1, AK9, ALDH3A2, ASS1, ST6GALNAC1, CHST9, AKR1C3 |
| 05016 | Huntington's disease | 6 | <0.01 | DNALI1, DNAI2, DNAH10, DNAH12, DNAH9, DNAH5 |
| 05418 | Fluid shear stress and atherosclerosis | 5 | <0.01 | CALM1, NQO1, CALML4, ASS1, GSTA1 |
| 05204 | Chemical carcinogenesis | 4 | <0.01 | ALDH3A1, AKR1C2, ADH1C, GSTA1 |
| 00730 | Thiamine metabolism | 2 | 0.01 | AK7, AK1 |
| 00830 | Retinol metabolism | 3 | 0.01 | DHRS9, RDH10, ADH1C |
| 00010 | Glycolysis/Gluconeogenesis | 3 | 0.01 | ALDH3A1, ALDH3A2, ADH1C |
| 00982 | Drug metabolism-cytochrome P450 | 3 | 0.01 | GSTA1, ALDH3A1, ADH1C |
| 00980 | Metabolism of xenobiotics by cytochrome P450 | 3 | 0.01 | ALDH3A1, ADH1C, GSTA1 |
| 04971 | Gastric acid secretion | 3 | 0.01 | CALML4, EZR, CALM1 |
| 00340 | Histidine metabolism | 2 | 0.01 | ALDH3A1, ALDH3A2 |
| 04744 | Phototransduction | 2 | 0.02 | CALML4, CALM1 |
| 05146 | Amoebiasis | 3 | 0.02 | SERPINB4, GNAL, SERPINB3 |
| 04070 | Phosphatidylinositol signaling system | 3 | 0.02 | CDS1, CALM1, CALML4 |
| 00410 | β-alanine metabolism | 2 | 0.02 | ALDH3A1, ALDH3A2 |
| 00350 | Tyrosine metabolism | 2 | 0.03 | ALDH3A1, ADH1C |
| 00071 | Fatty acid degradation | 2 | 0.04 | ADH1C, ALDH3A2 |
| 04962 | Vasopressin-regulated water reabsorption | 2 | 0.04 | AQP3, DYNC2H1 |
| 04728 | Dopaminergic synapse | 3 | 0.04 | CALM1, GNAL, CALML4 |
DEGs, differentially expressed genes.