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. 2019 Mar 28;11:70. doi: 10.3389/fnagi.2019.00070

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Copyright © 2019 Moir and Tanzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amyloid-β protein is an ancient and highly evolutionary conserved neuropepetide. Figure shows Aβ42 sequences across different vertebrate taxa. Conserved (blue) and non-conserved (red) amino acid substitutions among non-human species are highlighted. Adapted from Luna et al. (2013).