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. 2019 Mar 22;10:255. doi: 10.3389/fgene.2019.00255

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Copyright © 2019 Wu, Qiao, Zhao, Wu, Hu, Wu, Huang, Chen, Sun, Liu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FALEC modulated ECM1 expression by exerting its enhancer-like function in cis. (A) The relative loci of genes adjacent to FALEC. The scale bar represents 100 kb. (B) Depletion of FALEC specifically decreased expression of protein-coding gene ECM1 in HGC-27 and MGC-803 cells. (C) siRNA-induced knockdown of the ECM1 did not affect the transcription of its neighboring genes. ^∗∗P < 0.01. (D) Diagram of the FALEC DNA sequence cloned down-stream of Firefly luciferase in a pGL3-Promoter vector (pGL3-Promoter-FALEC-Reverse). (E) FALEC inserts result in a significant enhancement of transcription in GC cells, and depletion of FALEC resulted in a significant decrease in transcriptional enhancement compared with control in HGC-27 and MGC-803 cells. ^∗P < 0.05, ^∗∗P < 0.01.