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. 2019 Mar 22;10:462. doi: 10.3389/fimmu.2019.00462

Figure 3.

Figure 3

Treatment with P. histicola alone, Copaxone® alone, or the combination of P. histicola and Copaxone® resulted in decreased inflammation and demyelination in the brain and spinal cord of HLA-DR3.DQ8 transgenic mice induced with EAE. Representative hematoxylin and eosin (H&E)-stained images of the brain or Luxol-fast blue stained images of spinal cords of mice treated with P. histicola alone, Copaxone® alone, P. histicola and Copaxone®, or media. 20X Brain section (inset black boxes in 4X) show regions of inflammation. Similarly spinal cord sections are enlarged at 10X to show regions with inflammation and demyelination. Data are representative of 3 independent experiments (n = 5 mice per group).