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. 2019 Mar 22;10:462. doi: 10.3389/fimmu.2019.00462

Figure 6.

Figure 6

P. histicola but not Copaxone® mediates disease suppression through restoration of gut microbiota (A) Fecal samples were collected from pre-immunized HLA-DR3.DQ8 transgenic mice (Naïve/Nor), or mice immunized for EAE (EAE) and treated with Copaxone® (Cop) or P. histicola (PH). Fecal DNA was extracted, 16s rRNA (V3-V5) region was amplified, and sequenced on Illumina MiSeq platform. Two dimension Partial least square- dimension analysis (PLS-DA) scores plot of fecal microbiota from different treatment groups and naïve (Nor) mice with each dot representing a mice. (B) Box plot showing normalized relative abundance of Lactobacillus among different groups. (C) PLS-DA scores plot showing fecal microbiota profile from pre-immunized mice (Nor) or mice immunized for EAE (EAE) or Copaxone® plus P. histicola (Cop_plus_PH). (D) Box plot showing normalized relative abundance of Lactobacillus among different groups. Difference among groups were analyzed using one-way ANOVA (Kruskal–Wallis rank sum test) and FDR-adjusted p < 0.05.