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. 2019 Mar 21;10:515. doi: 10.3389/fimmu.2019.00515

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Copyright © 2019 Heming, Schulte-Mecklenbeck, Brix, Wolbert, Ruland, Klotz, Meuth, Gross, Wiendl and Meyer zu Hörste.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dimensionality reduction reveals distinct immune cell profiles of inflammatory neuropathies. (A) Principal component (PC) analysis (PCA) was performed using data from patients with chronic inflammatory demyelinating polyneuropathy (CIDP), Guillain-Barré syndrome (GBS), relapsing-remitting multiple sclerosis (RRMS), and idiopathic intracranial hypertension (IIH). Each circle represents a single patient; larger circles represent the group mean. The ellipses around each group mean point represent the confidence intervals. (B) The top 16 parameters contributing to PC1 and PC2 in the PCA are depicted. A long distance between a variable and the origin indicates a major influence of the corresponding variable on the PC. OCBs, oligoclonal bands; Ig, immunoglobulin.