Figure 5.

Inflammatory neuropathies show intra-disease heterogeneity characterized by CSF protein and monocytes. (A) The uniform manifold approximation and projection for dimension reduction (UMAP) (20), a recently published dimension reduction technique, was performed. Each circle represents a single patient and diagnosis is color coded. Based on the results of UMAP, patients were divided into group A and B as denoted. (B) Box plots show the CSF parameters that were significantly different between group A and group B. Boxes indicate the lower quartile, median, and upper quartile with whiskers extending to the furthest value within 1.5 times the interquartile range of the box. Outliers are identified individually. The statistical significance of the results was determined using the Mann-Whitney U-test for continuous variables (CSF protein, non-classical monocytes, intermediate monocytes, HLA-DR+CD4+CD8+ T cells) and the chi-squared test for the dichotomous variable (therapy). ^*p < 0.05, ^***p < 0.001. CIDP, chronic inflammatory demyelinating neuropathy; GBS, Guillain-Barré syndrome; RRMS, relapsing-remitting multiple sclerosis; IIH, idiopathic intracranial hypertension.