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. 2019 Mar 1;9(3):496–510.

Figure 8.

Figure 8

UCA1 promotes KRAS expression by sponging miR-590-3p. A, B. The protein and mRNA levels of KRAS were suppressed in Mpanc96 and HPAF-II cells after transfection with miR-590-3p compared to these levels in the corresponding cells transfected with miR-NC. C. The miR-590-3p binding sequence in the KRAS 3’UTR was predicted. D. The decrease in luciferase activity after the cotransfection of the 3’UTR-KRAS-WT construct and miR-590-3p into HEK293T cells was analyzed by a dual luciferase reporter assay. E, F. KRAS expression was assessed in PaTu8988 and PANC-1 cells after transfection with pSL-MS2-12X, UCA1-WT or UCA1-MUT. (*P<0.05, **P<0.01).