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GTP binding activity, but not transamidase activity of TG2 induces EMT. Western blot analysis of TG2, Vimentin and ZEB1 in (A) MCF7 and MDA-MB-231 cells; and (B) mock-transfected MCF7, TG2-transfected MCF7, control shRNA-transfected MDA-MB-231 and TG2 shRNA-transfected MDA-MB-231 cells. (C) Representative immunoblot shows TG2 expression in MCF7 stably transfected with vectors containing transamidase-inactive TG2 (TG2-C277S) and GTP-binding-inactive TG2 (TG2-R580A) constructs.
