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. 2019 Mar 1;9(3):597–607.

Figure 3.

Figure 3

MiR-205 overexpression inhibits EMT induction by transamidase-inactive TG2 that harbors GTP binding activity in breast cancer cells. qRT-PCR analysis of the relative expression of (A) miR-205 and (B) EMT markers ZEB1 and Vimentin in TG2-overexpressing MCF7 (MCF7/TG2-C277S) cells that are stably transfected with a vector containing control and miR-205 constructs, and TG2-knockdown MDA-MB-231 cells (MDA-MB-231/shTG2) that are stably transfected with vector harboring control and anti-miR-205 constructs. (C) Representative photographs show in vitro invasion assay results of transamidase-inactive TG2 (TG2-C277S) expressing MCF7 cells that are stably transfected with vectors containing control miRNA and miR-205, and TG2-knockdown MDA-MB-231 cells (MDA-MB-231/shTG2) that are stably transfected with anti-microRNA control and anti-miR-205 constructs.