The relationship between Rab1A expression and HER2, p-AKT and p-S6K1 expression. Expression of (A) HER2, (D) p-AKT and (G) p-S6K1 was analyzed by immunohistochemical (IHC) staining of CRC and adjacent normal tissues (scale bar, 100 µm). IHC analysis of (B) HER2, (E) p-AKT and (H) p-S6K1 expression in tumor and normal tissues. Percentage of specimens exhibiting negative or positive Rab1A expression and association of Rab1A with (C) HER2, (F) p-AKT and (I) p-S6K1 in CRC tumor specimens. *P<0.05, **P<0.01, ***P<0.001. CRC, colorectal carcinoma; ns, not significant.