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. 2019 Mar 7;41(5):2833–2843. doi: 10.3892/or.2019.7053

Figure 4.

Figure 4.

PD-L1 upregulates mTOR signaling in HNSCC cell lines. (A) Western blot analysis of T-Akt, P70S6K, p-P70S6KT389, p-AktS473 and GAPDH expression in PD-L1over, PD-L1RNAi and respective NC cells. (B) p-P70S6KT389 and p-AktS473 expression in each group was quantified. *P<0.05 and **P<0.01. PD-L1, programmed death-ligand 1; T-, total; P70S6K, 70 kDa ribosomal protein S6 kinase 1; p-, phosphorylated; Akt, protein kinase B; PD-L1over, PD-L1-overexpressing; PD-L1RNAi, PD-L1 knockdown; NC, negative control.