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. 2019 Mar 7;41(5):2833–2843. doi: 10.3892/or.2019.7053

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Copyright: © Zheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Rapamycin prevents the PD-L1-mediated effects on mTOR expression. (A) Western blot analysis of T-Akt, P70S6K, p-P70S6K^T389, p-Akt^S473 and GAPDH expression in PD-L1^over, PD-L1^RNAi and respective NC cells with or without rapamycin. (B) p-P70S6K^T389 and p-Akt^S473 expression in each group was quantified. *P<0.05 and **P<0.01. PD-L1, programmed death-ligand 1; T-, total; P70S6K, 70 kDa ribosomal protein S6 kinase 1; p-, phosphorylated; Akt, protein kinase B; PD-L1^over, PD-L1-overexpressing; PD-L1^RNAi, PD-L1 knockdown; NC, negative control; mTOR, mammalian target of rapamycin; RP, rapamycin.