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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Biochem Pharmacol. 2018 Nov 1;162:14–20. doi: 10.1016/j.bcp.2018.10.032

Figure 3. MDM2 over-expression disrupts Complex I activity through two distinct mechanisms.

Figure 3.

Mitochondrial MDM2 binds to mitochondrial DNA leading to decreased MT-ND6 expression, Complex I activity, and induced mitochondrial fragmentation and ROS. Conversely, cytosolic MDM2 sequesters NDUFS1 in the cytosol causing supercomplex dissociation, decreased Complex I activity, increased ROS, DNA damage, and apoptosis.