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In vitro efficacy of DOX-SLN compared to free doxycycline against B. melitensis inside J774A.1 cells
| Treatment | Concentration (μg/ml) | |||||
|---|---|---|---|---|---|---|
| 100 | 50 | 25 | ||||
| Mean CFUs ± SEM | Log CFUs reduction | Mean CFUs ± SEM | Log CFUs reduction | Mean CFUs ± SEM | Log CFUs reduction | |
| Doxycycline | 5.4 ± 0.03 | 0.9 | 5.6 ± 0.01 | 0.7 | 6.1 ± 0.04 | 0.2 |
| DOX-SLN | 3.5 ± 0.07 | 2.8 | 3.9 ± 0.03 | 2.4 | 3.6 ± 0.01 | 2.7 |
| Free SLN (blank) | 6.3 ± 0.01 | 0 | 6.3 ± 0.01 | 0 | 6.3 ± 0.01 | 0 |
| Negative Control | 6.3 ± 0.02 | 0 | 6.3 ± 0.02 | 0 | 6.3 ± 0.02 | 0 |
