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. 2019 Apr 3;17:110. doi: 10.1186/s12967-019-1854-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Examples of cytoplasmic alterations in hepatocytes characterized by hepatocytes with pale, granular appearance. a Normal hepatocytes from lean control animal (SD). b, c Hepatocytes with cytoplasmic alterations both from animals fed high fat/fructose/cholesterol diet (FFC). Scale bar 25 µm. Hematoxylin and eosin staining