. 2019 Apr 3;17:110. doi: 10.1186/s12967-019-1854-y

Table 4.

Associations between the circulating biomarkers and the histopathological findings

Elements	ORO-VIS	PSR-VIS	Iba1-VIS	Steatosis score	Fibrosis score	Inflammation score	CA score	PAS score
Biomarkers
TC	< 0.0001 (0.41)^a	0.01 (0.17)^a	< 0.0001 (0.45)^a	0.05 (0.16)^a	0.2 (0.14)	0.02 (0.26)^a	< 0.0001 (0.56)^a	0.3 (0.10)
TG	0.001 (0.28)^a	0.01 (0.17)^a	0.0007 (0.28)^a	0.2 (0.10)	0.04 (0.22)^a	0.009 (0.29)^a	< 0.0001 (0.49)^a	0.4 (0.09)
ALP	0.003 (0.23)^a	0.002 (0.25)^a	0.0006 (0.29)^a	0.11 (0.12)	0.04 (0.22)^a	0.008 (0.30)^a	< 0.0001 (0.55)^a	0.03 (0.24)^a
ALT	0.2 (0.06)	0.4 (0.02)	0.005 (0.20)^a	0.02 (0.21)^a	0.6 (0.05)	0.5 (0.07)	0.1 (0.15)	0.1 (0.15)
AST	0.02 (0.16)^a	0.01 (0.17)^a	0.2 (0.05)	0.1 (0.13)	0.01 (0.27)^a	0.2 (0.13)	0.03 (0.23)^a	0.9 (0.02)
AST:ALT	0.0005 (0.31)^a	0.0001 (0.35)^a	0.006 (0.20)^a	0.02 (0.20)^a	< 0.0001 (0.47)^a	0.008 (0.30)^a	0.0004 (0.42)^a	0.5 (0.07)
GLDH	0.001 (0.27)^a	0.007 (0.19)^a	0.003 (0.22)^a	0.2 (0.10)	0.002 (0.35)^a	0.03 (0.23)^a	0.0002 (0.44)^a	0.7 (0.05)
CRP	0.7 (0.01)	0.6 (0.01)	0.2 (0.04)	0.5 (0.03)	0.8 (0.03)	0.9 (0.02)	0.7 (0.04)	1 (0.00)

All response variables were transformed for normal distribution of residuals

ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, CRP C-reactive protein, CA cytoplasmic alterations, GLDH glutamate dehydrogenase, Iba1-VIS quantification of macrophages on Iba1 immunohistochemical stain, ORO-VIS quantification of lipid on oil red O stain, PAS positive periodic acid Schiff stain for glycogen, PSR-VIS quantification of collagen on picro-sirius red stain, TC total cholesterol, TG triglycerides

Data presented as p-value (R²)

^aSignificant result