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. 2019 Apr 3;17:110. doi: 10.1186/s12967-019-1854-y

Table 6.

Associations between the biochemical analyses of liver tissue content and the histopathological findings

Variable Triglycerides^ Cholesterol^ Glycogen^
Parametric findings
 ORO-VIS (lipid) < 0.0001 (0.59)a 0.0004 (0.27)a 0.0001 (0.32)a
 PSR-VIS (collagen) 0.4 (0.04) < 0.0001 (0.34)a 0.6 (0.01)
 Iba1-VIS (inflammation) 0.3 (0.03) < 0.0001 (0.39)a 0.9 (0.001)
Categorical scores
 Steatosis 0.006 (0.17)a 0.004 (0.24)a 0.1 (0.09)
 Fibrosis 0.4 (0.07) 0.006 (0.27)a 0.6 (0.05)
 Inflammation 0.3 (0.1) 0.0002 (0.39)a 0.9 (0.01)
 Cytoplasmic alterations 0.98 (0.00) < 0.0001 (0.73)a 0.2 (0.11)
 PAS positive 0.005 (0.29)a 0.4 (0.07) < 0.0001 (0.75)a

Iba1-VIS quantification of macrophages on Iba1 immunohistochemical stain, ORO-VIS quantification of lipid on oil red O stain, PAS positive periodic acid Schiff stain for glycogen, PSR-VIS quantification of collagen on picro-sirius red stain

Data presented as p-value (R2)

^Transformed

aSignificant result