Table 3.
Survival of breast cancer patients according to mean tumor ascorbate or HIF-1 pathway score
| Tumor ascorbatea | HIF-1 pathway scorea | ||||
|---|---|---|---|---|---|
| <mean | ≥ mean | <mean | ≥ mean | ||
| Disease-free survival | Mean days | 2772 | 3613 | 3865 | 2412 |
| 95% CI | (2142, 3402) | (3022, 4204) | (3286, 4443) | (1787, 3037) | |
| No. events | 10 | 4 | 3 | 11 | |
| p value | 0.173 | 0.01 | |||
| Disease-specific survival | Mean days | 2977 | 3613 | 4216 | 2439 |
| 95% CI | (2350, 3603) | (3022, 4204) | (3834, 4598) | (1824, 3054) | |
| No. events | 8 | 4 | 1 | 11 | |
| p value | 0.322 | 0.001 | |||
aTumor ascorbate mean: 0.2 nmol/μg DNA, n = 31 below the mean, n = 19 above the mean; Tumor HIF-1 pathway score median: 41.8 (HIF-1 pathway score calculated from relative protein levels of HIF-1α, CA-IX, BNIP-3 and VEGF); n = 28 below and n = 21 above the mean. Significance is indicated when p < 0.05