Fig. 3.

3D microengineered models of cardiac diseases. a Relevant gene expression changes in 2D and 3D-EHT cardiac tissue models of hypertrophic cardiomyopathy, reprinted with permission from [102]. b Sarcomere organization of cardiac tissues from patient-derived and gene-edited cells for modeling of BTHS with response to TAZ restoration, reprinted with permission from [27]. c Representative image of CMTs and twitch forces of CMTs from WT and patient-derived cells to study dilated cardiomyopathy, reprinted with permission from [103]. d Cardiac-related marker expression and electrical activity of WT and gene-edited cardiac tissues within constructs of different sized fibers, reprinted with permission from [100]