| CHASM* |
[27] |
Probability that the mutation gives the cells a selective survival advantage |
http://wiki.chasmsoftware.org/index.php/Main_Page |
| Condel |
[28] |
Combines FATHMM, mutation assessor etc. |
http://bg.upf.edu/fannsdb/ |
| FATHMM* |
[29] |
Distinguishes between cancer promoting and ‘neutral’ germline polymorphisms using hidden Markov models |
http://fathmm.biocompute.org.uk/about.html |
| Mutation assessor* |
[30] |
Based on evolutionary conservation of the affected amino acid in protein homologues |
http://mutationassessor.org/r3/ |
| Polyphen-2 |
[31] |
Uses straightforward physical and comparative considerations |
http://genetics.bwh.harvard.edu/pph2/ |
| SIFT |
[32] |
Based on sequence homology and the physical properties of amino acids |
http://sift.bii.a-star.edu.sg/ |
| TransFIC* |
[23] |
Transforms functional impact scores provided by other tools by taking into account the differences in basal tolerance to germline single nucleotide variants (SNVs) of genes that belong to different functional classes |
http://bg.upf.edu/transfic/home |
