Table 2. Properties of small molecule drug-like compounds.

Lipinkski’s rule of 5 [80]

- Molecular weight ≤500

- logP ≤5

- Hydrogen bond donors ≤5

- Hydrogen bond acceptors (all N and O atoms) ≤10

Further considerations [81]

- PSA ≤140 A2

- Rotatable bonds ≤10