Table 3. Programs that can be used to calculate structure-based druggability.

Name	References	Pocket search method	Druggability score
			Function	Descriptors
fPocket	[92]	Geometric criteria based on distance to predetermined points	Partial least square analysis	Hydrophobicity, normalized polarity and local hydrophobicity density
DoGSiteScorer	[100]	Geometric criteria based on 3D image enhancement techniques	Support vector machine	Depth, volume and relative number or apolar amino acids
SiteMap	[101]	Geometric and energetic criteria on 3D grids	Weighted sum of three descriptors	Hydrophilicity, degree of enclosure, number of site points