Table 2.
Histologic, Endoscopic, and Symptomatic Response to FFED in Responders and Nonresponders
| Responders (n = 50) |
Nonresponders (n = 28) |
||||||
|---|---|---|---|---|---|---|---|
| Pre Mean (SD) |
Post Mean (SD) |
P value | Pre Mean (SD) |
Post Mean (SD) |
P value | ||
| Histology | |||||||
| Peak eos/hpf | 62.0 (33.7) | 5.0 (4.1) | < .001a | 74.4 (36.4) | 62.1 (31.6) | .15 | |
| Distal eos/hpf | 55.9 (33.9) | 4.1 (3.9) | < .001a | 58.3 (37.6) | 51.5 (30.1) | .48 | |
| Proximal eos/hpf | 43.9 (32.4) | 2.6 (3.3) | < .001a | 63.7 (36.7) | 44.8 (33.1) | .03a | |
| Visual findings | Count (%) | Count (%) | P value | Count (%) | Count (%) | P value | |
| Furrow | 34 (71) | 17 (35) | < .001a | 22 (79) | 23 (82) | 1.00 | |
| Edema | 32 (67) | 12 (25) | < .001a | 21 (75) | 20 (74) | 1.00 | |
| Exudate | 24 (50) | 1 (2) | < .001a | 17 (61) | 17 (61) | 1.00 | |
| Rings | 5 (10) | 6 (12) | 1.00 | 4 (14) | 4 (14) | 1.00 | |
| Stricture | 0 (0) | 0 (0) | — | 1 (4) | 0 (0) | — | |
| Symptoms | Count (%) | Count (%) | P value | Count (%) | Count (%) | P value | |
| Abdominal pain | 25 (50) | 15 (30) | .03a | 14 (50) | 11 (39) | .58 | |
| Slow eating | 21 (42) | 18 (36) | .55 | 12 (43) | 6 (21) | .08 | |
| Early satiety | 21 (42) | 13 (26) | .06 | 11 (39) | 5 (18) | .04a | |
| Poor appetite | 16 (32) | 5 (10) | .01a | 9 (32) | 5 (18) | .34 | |
| Dysphagia | 15 (30) | 11 (22) | .45 | 12 (43) | 9 (32) | .58 | |
| Vomiting | 15 (30) | 4 (8) | .01a | 9 (32) | 6 (21) | .55 | |
| Food impaction | 14 (28) | 5 (10) | .04a | 5 (18) | 3 (11) | .68 | |
| Gagging/choking | 13 (26) | 3 (6) | .01a | 5 (18) | 4 (14) | 1.00 | |
| Regurgitation | 12 (24) | 2 (4) | .01a | 8 (29) | 2 (7) | .08 | |
| Poor weight gain | 12 (24) | 5 (10) | .07 | 6 (21) | 2 (7) | .13 | |
| Pockets/spits after chewing | 12 (24) | 1 (2) | .01a | 6 (21) | 2 (7) | .13 | |
| Feeding difficulties | 12 (24) | 5 (10) | .12 | 9 (32) | 5 (18) | .29 | |
| Nausea | 9 (18) | 7 (14) | .77 | 9 (32) | 2 (7) | .05a | |
| Chest pain | 6 (12) | 4 (8) | .68 | 6 (21) | 0 (0) | .04a | |
| Heartburn | 5 (10) | 5 (10) | 1.00 | 5 (18) | 3 (11) | .68 | |
| Nocturnal awakening | 5 (10) | 1 (2) | .13 | 3 (11) | 1 (4) | .48 | |
| Odynophagia | 4 (8) | 5 (10) | 1.00 | 4 (14) | 1 (4) | .37 | |
FFED, 4-food elimination diet.
a
P < .05.