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. 2019 Apr;60(4):459–465. doi: 10.2967/jnumed.118.213488

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FIGURE 2. — Site-specific conjugation and preclinical evaluation of ⁸⁹Zr-^ssDual-5B1. (A) Application of glycan engineering and bioorthogonal click-chemistry for synthesis of site-specific dual-labeled immunoconjugate. (B–D) PET, PET/CT, and NIRF imaging of orthotopic pancreatic ductal adenocarcinoma model at 120 h after injection demonstrate potential of ⁸⁹Zr-^ssDual-5B1 for identifying primary tumor (T), metastasis (M), and sentinel lymph nodes (LN). (E and F) Histology (left), autoradiography (center), and fluorescence microscopy (right) of resected tissue from mice injected with ⁸⁹Zr-^ssDual-5B1 confirm colocalization with cancer antigen 19-9 expression. (E) BxPC3 xenograft. (F) Metastatic foci. Adapted from (17).