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. 2019 Mar 28;10:278. doi: 10.3389/fgene.2019.00278

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Copyright © 2019 Zhang, Duan, Cun and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of AS events profiling in BRCA cohort. (A) Flowchart for profiling AS of BRCA. (B) Illustration for splicing pattern of seven types of AS events, including Exon Skip (ES), Alternate Promoter (AP), Alternate Terminator (AT), Alternate Donor site (AD), Alternate Acceptor site (AA), Mutually Exclusive Exons (ME), and Retained Intron (RI). (C) Seven types of AS events and corresponding genes from the 645 BRCA patients were depicted according to classified P-value of 0.05. The gray bars represent the prognosis irrelevant AS events and involved genes. The color bars represent the prognostic AS events and parent genes filtered by univariate Cox analyses. (D) Upset plot of gene interactions between the seven types of prognosis-related AS events (n = 3071). The yellow dot lines represent that one gene could have two types of prognostic AS events while blue dot lines represent the genes which occupied up to three types of survival-associated AS.